The 1942 Louisville Cardinals football team was an American football team that represented the University of Louisville as a member of the Kentucky Intercollegiate Athletic Conference (KIAC) during the 1942 college football season. In their seventh and final season under head coach Laurie Apitz, the Cardinals compiled a 2–3 record.
Louisville was ranked at No. 473 (out of 590 college and military teams) in the final rankings under the Litkenhous Difference by Score System for 1942.
Louisville did not field a football team in 1943 or 1944 during the height of World War II.
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