Nifurzide is a nitrofuran derivative and intestinal anti-infectious agent active against Escherichia coli.
Synthesis
Esterification of 5-nitrothiophene-2-carboxylic acid (1) with ethanol gives the ester (2). Treatment with hydrazine forms its hydrazide (3). Nifurzide is the hydrazone formed between (3) and 5-nitrofuran-2-acrylaldehyde (4).
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