Dynein light chain Tctex-type 1 is a protein that in humans is encoded by the DYNLT1 gene.
Cytoplasmic dynein is the major motor protein complex responsible for minus-end, microtubule-based motile processes. Each dynein complex consists of 2 heavy chains that have ATPase and motor activities, plus a group of accessory polypeptides. TCTEX1 is a dynein light chain involved in cargo binding (Chuang et al., 2005).[supplied by OMIM]
In cancer patients, DYNLT1 expression has been linked to both higher and lower survival rates, depending on cancer type.
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